Removal · field guidance

4-week IgG seroconversion window

Most patients seroconvert IgG against Borrelia within 4-6 weeks of infection, the basis for repeat testing of early-negative cases.

Steps

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01
IgM antibodies typically appear 2-4 weeks after infection.
02
IgG antibodies follow at 4-6 weeks and continue to rise for months.
03
A negative test in the first 2 weeks should not exclude Lyme if EM is present.
04
Repeat serology 4-6 weeks after symptom onset to capture seroconversion.
05
Antibiotics started within the first week may blunt or delay seroconversion.

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