Generations of pediatricians withheld doxycycline from young children because of a tetracycline-class warning about permanent tooth staining. CDC and AAP now state that short courses of doxycycline at standard pediatric doses do not cause visible tooth staining or enamel hypoplasia, and the drug should not be withheld from suspected RMSF, ehrlichiosis, or anaplasmosis on that basis.
A 2001 NEJM trial by Robert Nadelman and colleagues showed that a single 200 mg oral dose of doxycycline within 72 hours of removing an…
Untreated Rocky Mountain spotted fever kills roughly 20 to 25 percent of patients, with most deaths in the second week of illness.…
The hallmark spotted rash of Rocky Mountain spotted fever does not appear until day 2 to 5 of illness, and roughly 10 percent of cases…
When a clinician suspects ehrlichiosis or anaplasmosis but the antibody titers are too cross-reactive to call, PCR on whole blood drawn…
Ehrlichia chaffeensis ehrlichiosis classically presents with fever, headache, and a triad of laboratory findings: leukopenia,…
Ehrlichia ewingii ehrlichiosis was first recognized in human disease in 1999, almost exclusively in immunocompromised patients - HIV,…